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appeared in the British and American literature regarding St John s wort since 2002 However a meta-analysis of 20 clinical trials of St John s wort recently published in German (Roder et al 2004) still concludes that St John s wort is more effective than placebos and of similar effectiveness to synthetic antidepressants with lower drop-out rates They supported the positive view of the German health authority that St John s wort is a rstline treatment for milder forms of depression A recent trial conducted in Germany but published in English compared Hypericum extracts to the second generation antidepressant drug (SSRI) paroxetine (Szegedi et al 2005) in patients with moderate to severe depression They concluded that Hypericum was at least as effective as paroxetine and that it was better tolerated.

22:6

St John s wort is marketed in Britain and the USA as a dietary supplement but is a prescription drug in Germany; it has recently been banned for over the counter sale in Ireland and is only available there on prescription The available data suggest that, even if it does have some bene t in treating depression, it should not be taken with other prescription medications and probably should not be used as a routine, long-term supplement for people not suffering from depression It should be used as a medicine of herbal origin rather than a dietary supplement It was included in this chapter largely because of the scale of its usage, with perhaps as many as two million Britons having tried it at some time.

carries three bits of information. Note that the assignments of bits to constellation points in Figure 1.6 is such that adjacent points differ by only one bit. Such an assignment is called Gray code order. Since it is most probable that errors will move from a point to an adjacent point, this reduces the probability of bit error. 0

Tea extracts Tea is a drink made from the dried leaves of Camellia sinensis; it is said to be the second most popular drink in the world after water All tea starts as green but if the rolled and cut leaves are allowed to stand and ferment for 1 3 days before drying it becomes black In green tea the enzyme that causes the blackening is inactivated by heat treatment which prevents blackening Oolong tea is fermented for a shorter period and its colour and taste are between green and black tea Tea leaves contain high quantities of polyphenols, which make up 20 30% of their dry weight When tea leaves are rolled and crushed during processing, the enzyme polyphenol oxidase converts catechins (categorised earlier as avonols) to polymeric forms, which give the fermented oolong and black teas their characteristic colours.

non-GMP may also be created in order to operate both in an ef cient way. The two parts can still communicate. The impact segments should be validated and placed under change control, while the noimpact segments need not be. The validated impact system does not need to be monitored by an Independent Monitoring System, as the validation will show that the BMS works as intended or at least where the problems are. Good Engineering Practice (GEP) is important when designing and implementing a HVAC/BMS system. This is described in 6. The whole system should, of course, be subject to GEP. For the no-impact segments of the system, GEP is suf cient for documentation. The parts of the system that directly or indirectly impact the product quality need validation in addition to GEP.